演講者：
單 位：
生物統計研究所
日 期：2010年9月15日 PM 14:30
地 點：國立高雄大學理學院408室
講 題：
摘 要：
Molecular phylogenetics is the study of evolutionary relationships among organisms or genes by a combination of molecular biology and statistical techniques. Fundamental to these are the mathematical models used to describe the evolutionary changes in DNA and protein sequences.
A basis process in the evolution of DNA sequences is the change in nucleotide with time. To detect nucleotide substitutions in DNA sequences, we usually rely on comparison of sequences that have been derived from a common ancestral sequence. The number of nucleotide substitutions between two sequences is a quantity of leading importance in molecular evolution because it is used to compute the rate of evolution, to estimate divergence time, and to reconstruct phylogenetic trees by many methods. In the past two decades, a number of methods have been proposed for this purpose and the relative performances of those methods have been critically examined by simulation experiments. In this talk, we will introduce the frequently used methods for estimating the rate of nucleotide substitutions and applications in the phylogenetic studies. We will conclude with speculations on the future course of molecular evolutionary analyses.