2011/11/30 羅主斌教授專題演講
演講者：
單 位：
日 期：2011年11月30日 PM 14:30
地 點：國立高雄大學理學院408室
講 題：
摘 要：
The heart is a very complex organ with multiscale structures, from microscopic single cell or even molecular ion channel, the mesoscopic tissue, to the macroscopic whole organ. The corresponding modeling techniques are varying with different scales. In this talk, I will mainly focus on the modeling issues of the cell and channel scales, especially the gating mechanism of ion channel. Ion channel plays important role in physiological functionality. Three types of modeling approaches for the gating mechanism will be introduced and compared: Hodgkin-Huxley, Markov chain, and Smoluchowski (Fokker-Planck type model), more refined for the later. With more understanding of the structures and working mechanisms of ion channels, the speedup of drug design and adoption of more suitable therapy policy are expected. As examples, I will show our recent works on some genetic heart diseases: Timothy syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) to clarify the relationship. Finally, some modeling (computation) challenges and perspectives will be addressed, such as healthy human heart modeling, GPU computation, drug developments…