演講者：洪子倫教授

單　位：逢甲大學應用數學系

日　期：2012年12月19日　PM 14:30

地　點：國立高雄大學理學院408室

講　題：Investigation of the spatiotemporal responses of nanoparticles in tumor tissues with a small-scale mathematical model

摘　要：

The transport and accumulation of anticancer nanodrugs in tumor tissues are affected by many factors such as particle properties, vascular density and leakiness, and interstitial diffusivity, etc. It is important to understand the effects of these factors on the detailed drug distribution in the entire tumor for an effective treatment. In this study, we developed a small-scale mathematical model to systematically study the spatiotemporal responses and accumulative exposures of macromolecular carriers in localized tumor tissues. We chose various dextrans as model carriers and studied the effects of vascular density, permeability, diffusivity, and half-life of dextrans on their spatiotemporal concentration responses and accumulative exposure distribution to tumor cells. The relevant biological parameters were obtained from previously experimental results of Dreher group. The area under concentration-time response curve (AUC) quantifies the extent of tissue exposure to a drug and therefore is considered to be more reliable in assessing the extent of the overall drug exposure than individual concentrations. The results show that 1) a small macromolecule can penetrate deep into the tumor interstitium and produce a uniform but low spatial distribution of AUC; 2) large macromolecules produce high AUC in the perivascular region, but low AUC in the region distant away from vessels; 3) medium-sized macromolecules produce a relatively uniform and high AUC in the tumor interstitium between two vessels; 4) enhancement of permeability can elevate the level of AUC, but affect little on its uniformity while enhancement of diffusivity is able to raise the level of AUC and improve its uniformity; 5) a longer half-life can produce a deeper penetration and a higher level of AUC distribution. The numerical results indicate that a long half-life carrier in plasma and a high interstitial diffusivity are the key factors to produce a high and relatively uniform spatial AUC distribution in the interstitium. Also, a large-scale simplified model, currently under investigation, will be adressed too. Besides, drug transport in these models can be changed to nutrient transport that can help developing tumor growth model with vascularture.